The evolutionary patterns of cancer subpopulations under immune selection

Our immune system confer a strong selective pressure on cancer cells. However, how cancer cells evolve to escape the immune surveillance is poorly understood. We integrate multi-region sequencing, single cell transcriptomics and computational models to understand how cancer cells evolve to escape our immune surveillance and how immune selection drive the evolutionary trajectories of cancer cells.

Hu Lab
Hu Lab
Institute of Synthetic Biology

Our group intersects evolutionary genetics, cancer genomics and computational modeling to delineate the evolutionary dynamics of tumor growth and metastasis.